منابع مشابه
Reversing cancer stemness
lethality of malignant breast cancer in human patients. Although various targeted and non-targeted therapies can occasionally control the progress of breast cancer, a significant portion of patients develop resistance to chemotherapy and experience metastatic recurrence. The epithelial to mesenchymal transition (EMT), a key developmental program in embryogenesis, has been found to be closely in...
متن کاملCancer stem cells and stemness markers in oral squamous cell carcinomas.
Head and neck squamous cell carcinoma (HNSCC) is one of the world top ten most common cancers with its highest occurrence in the Indian subcontinent and different aggressive and etiological behavioural patterns. The scenario is only getting worst with the 5 year survival rates dropping to 50%, persistent treatment failures and frequent cases of relapse/recurrence. One of the major reasons for t...
متن کاملSinomenine hydrochloride inhibits breast cancer metastasis by attenuating inflammation-related epithelial-mesenchymal transition and cancer stemness
Sinomenine hydrochloride (SH) has been investigated for its anti-tumor growth effect. We have previously reported that SH inhibited breast cancer cell proliferation via MAPKs signaling. However, whether SH could inhibit tumor metastasis has not been fully explored. In this study, we found that SH suppressed the metastasis potential of breast cancer cells. The wound healing and transwell assays ...
متن کامل“De-coding” Stemness Pathways in Cancer
Submit Manuscript | http://medcraveonline.com Abbreviations: ncRNAs: Noncoding RNAs; miRs: MicroRNAs; lncRNAs: Long noncoding RNAs; RISC: RNA-Induced-SilencingComplex; mRNAs: Messenger RNAs; CLL: Chronic Lymphocytic Leukemia; RREB1: Ras-Responsive Element-Binding Protein 1; HK2: Hexokinase 2; AldoA: Aldolase A; GPD2: Glycerol-3-phosphate dehydrogenase-2; Xist: X Inactive Specific Transcript; XC...
متن کاملCisplatin induces stemness in ovarian cancer
The mainstay of treatment for ovarian cancer is platinum-based cytotoxic chemotherapy. However, therapeutic resistance and recurrence is a common eventuality for nearly all ovarian cancer patients, resulting in poor median survival. Recurrence is postulated to be driven by a population of self-renewing, therapeutically resistant cancer stem cells (CSCs). A current limitation in CSC studies is t...
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ژورنال
عنوان ژورنال: Cancer Translational Medicine
سال: 2017
ISSN: 2395-3977
DOI: 10.4103/ctm.ctm_69_16